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Using mother-of-pearl (nacre) or decorative shells in a fish tank is generally safe for hard-water setups, but it will slowly dissolve and increase your water's pH, carbonate hardness (KH), and general hardness (GH) over time. It is well-suited for African cichlids, livebearers (like mollies), or brackish tanks, but should be avoided or monitored closely in soft-water or low-pH setups (like tetra or betta tanks).