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This season of the popular medical drama features Dr. Gregory House (Hugh Laurie) tackling complex medical cases while selecting a new team of doctors, including Kal Penn, Peter Jacobson, and Olivia Wilde. The season was impacted by the 2007-2008 Writers Guild of America strike, resulting in a reduced number of episodes. The main cast of Season 4 included Hugh Laurie as Dr. Gregory House, Lisa Edelstein as Dr. Lisa Cuddy, Omar Epps as Dr. Eric Foreman, and Robert Sean Leonard as Dr. James Wilson. Notable recurring characters were Anne Dudek as Dr. Amber Volakis, Peter Jacobson as Dr. Chris Taub, Kal Penn as Dr. Lawrence Kutner, and Olivia Wilde as Dr. Remy "Thirteen" Hadley. Some of the episode titles in Season 4 include "Alone," "The Right Stuff," "97 Seconds," and the two-part finale "House's Head" and "Wilson's Heart". The season finale revolves around a bus crash that House survives and his struggle to recall a fellow passenger he believes was seriously ill.