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used w/Rare OOP music soundtrack CD Sampler! Osmosis Jones (2001) is a live-action/animated buddy cop comedy where an anthropomorphic white blood cell cop, Osmosis Jones (Chris Rock), teams up with a cold pill (David Hyde Pierce) to stop a deadly virus (Laurence Fishburne) from killing their human host, Frank (Bill Murray). Directed by the Farrelly brothers for live-action and Tom Sito/Piet Kroon for animation, the film blends the "City of Frank" (the human body) with the outside world, following Jones and Drix as they fight the virus Thrax within a 48-hour deadline.