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Titled "The Spider or the Man?", Peter Parker becomes deeply conflicted over the burden of his dual identity and the toll it takes on his life with Gwen Stacy. Desperate to live a normal life, he drinks a mysterious serum he brewed in ESU's labs designed to rid him of his spider powers once and for all. Instead of curing him, the formula triggers a horrific genetic mutation, causing four additional arms to sprout from his body, leading directly into the iconic six-armed Spider-Man saga. Major Bronze Age milestone issue celebrating the 100th issue of the series, featuring the first appearance of the six-armed Spider-Man mutation and historical cover homages. Characters: Spider-Man (Peter Parker), Dr. Curt Connors, Gwen Stacy, Harry Osborn, and J. Jonah Jameson.